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Suriyaprakash, T. N. K.
- Formulation and Evaluation of Propanolol HCl Controlled Porosity Osmotically Controlled Tablet
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Authors
Affiliations
1 Department of Pharmaceutics, Periyar College of Pharmaceutical Sciences, K. Sathanoor Main Road, Tiruchirapalli-620021, IN
1 Department of Pharmaceutics, Periyar College of Pharmaceutical Sciences, K. Sathanoor Main Road, Tiruchirapalli-620021, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 6 (2010), Pagination: 378-380Abstract
The objective of the present study is to formulate once daily controlled porosity osmotic tablet of Propanolol HCl for the treatment of Hypertension and to reduce the pill burden by avoiding dosing frequency. Controlled porosity osmotic tablets have an advantage of avoiding cost and labor. Six batches (F1-F6) of osmotic tablets were made with Mannitol, KCl and NaCl as osmotic agent by wet granulation technique. The granules were evaluated for precompression properties. The granules were compressed into tablet using Rotary tablet compression machine. The tablets were coated with Ethyl Cellulose (F1E-F6E) and Cellulose Acetate (F1C-F6C) as coating polymer i.e. semipermeable membrane. The tablets were subjected to evaluation parameters like weight variation, hardness, friability, % weight increase for coated tablet and in-vitro dissolution using USP Type I apparatus. All batches compiles with pharmacoepial standards. Among the twelve batches F5C showed sustained release over a period of 20 hrs with 80.59% drug release. The best formulation was subjected to stability studies for 3 months 45°C and 70% RH.Keywords
Propanolol HCl, Controlled Porosity Osmotic Tablet, Ethyl Cellulose, Cellulose Acetate.- Design and Development of Taste Masked Cefpodoxime Dispersible Tablets
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Authors
Affiliations
1 Department of Pharmaceutics, Al Shifa College of Pharmacy, Poonthavanam (P.O.), Kizattur, Perinthalmanna, Malappuram (Dt.), Kerala. Pin – 679 325, IN
1 Department of Pharmaceutics, Al Shifa College of Pharmacy, Poonthavanam (P.O.), Kizattur, Perinthalmanna, Malappuram (Dt.), Kerala. Pin – 679 325, IN